Peroxiredoxin 5 induction in response to PRRSV infection restricts viral proliferation by inhibiting lipid biosynthesis - PubMed
5 hours ago
- #lipid biosynthesis
- #PRDX5
- #PRRSV
- PRRSV infection induces peroxiredoxin 5 (PRDX5) expression.
- Nonstructural protein 4 (nsp4) of PRRSV is the most potent inducer of PRDX5.
- Reactive oxygen species (ROS) from PRRSV infection or nsp4 overexpression upregulate PRDX5.
- PRDX5 inhibits lipid synthesis by inactivating the AMPK-ACC1 pathway, independent of its peroxidase activity.
- PRDX5 suppresses PRRSV proliferation by disrupting lipid production, and exogenous lipids restore viral multiplication.
- PRDX5 inhibits PRRSV infection by antagonizing the viral release stage.