LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery - PubMed
4 hours ago
- #AI-driven discovery
- #autonomous lab
- #mRNA delivery
- LUMI-lab is an AI-driven autonomous platform for molecular discovery and optimization.
- It integrates a transformer-based foundation model with an active-learning workflow to overcome data scarcity.
- The platform autonomously synthesized and screened over 1,700 lipid nanoparticles (LNPs).
- Discovered brominated lipid tails as a feature enhancing mRNA delivery efficiency.
- Top-performing lipid, LUMI-6, achieved 20.3% gene editing efficacy in mice lung epithelial cells.
- Demonstrates potential for advancing next-generation RNA delivery technologies.