Metronomic Chemotherapy Induces Metabolic Reprogramming in Cancer Cells that Modulates Mature Regulatory Dendritic Cell Function to Stimulate Antitumor Immunity - PubMed
4 hours ago
- #Metronomic Chemotherapy
- #Cancer Metabolism
- #Immune Memory
- Metronomic chemotherapy involves frequent, low-dose drug administration to induce anti-tumor immunity.
- It activates ATF4 in tumor cells, leading to metabolic changes and increased asparagine (Asn) release.
- Asn binds to AXL on mature regulatory dendritic cells (mregDCs), reducing PD-L1 expression.
- Lower PD-L1 on mregDCs promotes memory-like CD8+ T cell generation, enhancing immune memory.
- This mechanism suggests a way to optimize chemotherapy for better immune responses.