Mitochondrial RNA degradation regulates differentiation, stemness, and immune sensitivity in acute myeloid leukemia - PubMed
4 hours ago
- #mitochondrial RNA
- #immune sensitivity
- #acute myeloid leukemia
- Mitochondrial RNA (mtRNA) turnover is increased in Acute Myeloid Leukemia (AML) cells and stem cells.
- The mitochondrial degradosome (SUV3 and PNPase) is upregulated and crucial for degrading mtRNA and mitochondrial dsRNA in AML.
- Depletion of SUV3 or PNPase leads to dsRNA accumulation, stimulating IFN-I signaling.
- This IFN-I signaling induces AML differentiation, reduces stemness, and increases sensitivity to immune-mediated cytotoxicity.
- The study reveals mitochondrial RNA regulation as a key mechanism influencing AML behavior and immune response.