Dunhuang Daxiefei Decoction ameliorates acute lung injury via the HIF-1α/glycolysis/H3K18la axis - PubMed
5 hours ago
- #acute lung injury
- #HIF-1α glycolysis
- #traditional Chinese medicine
- Dunhuang Daxiefei Decoction (DXFD) alleviates acute lung injury (ALI) in mice and reduces pro-inflammatory cytokines.
- DXFD works by inhibiting HIF-1α-driven glycolysis and reducing histone H3K18 lactylation (H3K18la), which suppresses M1 macrophage polarization.
- Multi-omics analysis showed DXFD normalizes HIF-1α-associated inflammatory and glycolytic pathways activated in ALI.
- Molecular docking and dynamics simulations indicate baicalin in DXFD stably binds to HIF-1α, supporting its mechanism of action.
- HIF-1α overexpression partially reverses the protective effects of DXFD, confirming its role in the pathway.