Gut microbiota-intestinal barrier crosstalk: mechanistic advances, disease relevance, and public health implications - PubMed
4 hours ago
- #gut microbiota
- #intestinal barrier
- #chronic disease prevention
- The gut microbiota and intestinal barrier have a bidirectional crosstalk crucial for intestinal and systemic health.
- Gut microbiota regulate barrier integrity via metabolites like short-chain fatty acids (SCFAs), indole derivatives, and bile acids, affecting tight junctions, mucin, epithelial repair, and immunity.
- Barrier dysfunction can lead to microbial translocation, endotoxemia, and chronic inflammation, contributing to diseases such as inflammatory bowel disease, type 2 diabetes, liver disease, and neurodegenerative disorders.
- Microbiota-targeted interventions (e.g., prebiotics, probiotics, diet, fecal transplantation) show potential to restore barrier homeostasis but face challenges in study heterogeneity, causal validation, and clinical translation.
- The gut microbiota-intestinal barrier axis is a promising target for prevention-oriented public health strategies, requiring future research on causal validation, standardized methods, and equitable implementation.