TMEM106B deficiency exacerbates α-synuclein aggregation in Parkinson's disease - PubMed
6 days ago
- #α-synuclein aggregation
- #Parkinson's disease
- #TMEM106B
- TMEM106B deficiency is linked to increased α-synuclein aggregation in Parkinson's disease.
- TMEM106B levels are reduced in the brains of Parkinson's disease patients.
- Knockdown of TMEM106B leads to impaired lysosomal acidification and lipid metabolism disorders.
- Lipid droplets promote α-synuclein aggregation, enhancing fibril seeding activity and neurotoxicity.
- TMEM106B deficiency slows α-synuclein degradation by reducing cathepsin D activity.