TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress - PubMed
6 hours ago
- #LiverSurgery
- #TLR4
- #Tregs
- TLR4 in Tregs plays a crucial role in protecting against liver ischemia-reperfusion (I/R) injury.
- Decreased hepatic Treg abundance correlates with increased liver injury in patients undergoing hepatic resections.
- Treg-specific Tlr4 knockout mice (Treg-Tlr4-/-) showed exacerbated liver injury post-I/R.
- Adoptive transfer of WT Tregs, but not Tlr4-deficient Tregs, alleviated liver injury in mice.
- Tlr4-deficient Tregs exhibited impaired IL-10 production due to reduced MyD88/ERK/CREB pathway activation.
- Exogenous IL-10 administration rescued hepatic dysfunction in Treg-Tlr4-/- mice.
- Findings suggest TLR4 in Tregs as a potential therapeutic target to reduce postoperative complications in liver surgery.