Integrated multi-omics analysis reveals that MARCKS reprograms the immunosuppressive microenvironment to drive hepatocellular carcinoma progression - PubMed
14 hours ago
- #MARCKS
- #Immunosuppression
- #Hepatocellular carcinoma
- MARCKS is significantly upregulated in hepatocellular carcinoma (HCC) tissues and linked to aggressive features and poor prognosis.
- Integrated multi-omics analysis (bulk transcriptomics, single-cell RNA sequencing, spatial transcriptomics) reveals MARCKS's role in HCC.
- MARCKS expression is enriched in myeloid cells within the tumor microenvironment, promoting immunosuppression.
- MARCKS enhances JAK/STAT3 signaling and M2-like macrophage polarization, contributing to immune evasion.
- Silencing MARCKS reduces STAT3 phosphorylation, suppresses tumor growth, and decreases M2 macrophage polarization.
- MARCKS is identified as a potential therapeutic target for overcoming immunosuppression in HCC.