Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34 kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites - PubMed
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- #vector bites
- #human challenge trial
- #antibody response
- Study assessed antibody responses to Anopheles SG6-P1 and Aedes N-term 34 kDa salivary peptides.
- Randomised human-challenge trial with controlled exposures to mosquito bites.
- Participants received either 35 or 305 bites from Anopheles and Aedes species.
- Anti-gSG6-P1 IgG levels increased slightly in response to 305 An. minimus bites.
- Antibody half-life was estimated at 421 days.
- Small magnitude of antibody boosting observed.
- Future research needed to validate serological markers of vector exposure.