Targeted H2S Delivery System Attenuates Blood-Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway - PubMed
2 days ago
- #H2S
- #ferritinophagy
- #spinal cord injury
- Targeted H2S delivery system (SPRC@MPDA-RGD) attenuates blood-spinal cord barrier (BSCB) disruption after spinal cord injury (SCI).
- The nanoparticle utilizes αvβ3 integrin overexpression on endothelial cells post-SCI for precise delivery to the BSCB.
- SPRC@MPDA-RGD delivers S-propargyl-cysteine (SPRC) and scavenges reactive oxygen species (ROS), upregulating cystathionine γ-lyase (CSE) and stimulating endogenous H2S production.
- H2S activates the PI3K/Akt/mTOR pathway, suppressing ferritinophagy, reducing ferritin degradation, and inhibiting ferroptosis.
- This nanotherapeutic strategy combines H2S production and ROS scavenging to promote BSCB repair, showing potential for SCI treatment.