Liver sinusoidal endothelial TGF-β signaling accelerates partial endothelial-mesenchymal transition and MASH through Notch - PubMed
4 hours ago
- #MASH
- #TGF-β signaling
- #Endothelial-mesenchymal transition
- Liver sinusoidal endothelial cells (LSECs) play a crucial role in MASH progression through TGF-β signaling.
- A unique biphenotypic cell population co-expressing LSEC and mesenchymal markers was identified in MASH-affected livers.
- Partial endothelial-mesenchymal transition (EndMT) in LSECs is driven by TGF-β signaling and contributes to MASH progression.
- Notch signaling in LSECs, activated by TGF-β, is essential for generating biphenotypic cells and advancing MASH.
- Inhibition of TGF-β signaling in LSECs suppresses partial EndMT and attenuates MASH progression.
- The study highlights TGF-β/Notch axis in LSECs as a promising therapeutic target for MASH.