Cordycepin Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Inhibiting IL-6/IL-6R-Mediated p38 MAPK and NF-κB Activation Through Adenosine A2A Receptor Stimulation - PubMed
6 hours ago
- #Anti-inflammatory Mechanism
- #Ulcerative Colitis
- #Cordycepin
- Cordycepin (COR) from Cordyceps militaris shows protective effects against dextran sulfate sodium (DSS)-induced ulcerative colitis in mice and human colonic epithelial cells.
- The protective mechanism involves activation of adenosine A2A receptor (A2AAR), leading to increased intracellular cAMP levels, as blocked by the antagonist SCH58261.
- COR inhibits IL-6/IL-6R signaling, reducing phosphorylation and activation of p38 MAPK and NF-κB p65, thereby alleviating inflammation and restoring intestinal barrier function.