Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases - PubMed
6 hours ago
- #Biomarkers
- #Proteomics
- #Liver Disease
- The study aimed to identify protein markers for chronic liver disease (CLD) and its progression, and develop a protein-based risk prediction model.
- Using proteome-wide Mendelian randomization (MR) and other methods, 16, 5, and 4 plasma proteins were linked to MASLD, ALD, and cirrhosis, with IGSF3, FTCD, DCXR, ADH1B, and ACY1 associated with CLD progression.
- Genetically predicted modifiable factors like BMI and type 2 diabetes were connected to CLD-related proteins, and proteomic-based models showed high predictive performance for ALD, liver cancer, and liver failure in a healthy population.