Breathing new life into T-cell receptor-engineered T-cell therapy in solid tumors: enhancing strategies to expand the universality of precision therapy - PubMed
5 hours ago
- #solid tumors
- #TCR-T therapy
- #precision therapy
- TCR-engineered T-cell therapy (TCR-T) shows promise for solid tumors with a broader therapeutic window and stronger tumor-killing ability than CAR-T and TIL therapies.
- Current clinical efficacy of TCR-T therapy is still limited; challenges include improving TCR affinity, expanding target antigens, and refining production processes.
- Recent efforts focus on overcoming limitations through multimodal synergistic strategies and efficient in vitro production to enhance precision therapy.
- The goal is to expand TCR-T therapy's applicability to benefit more patients with solid tumors.