Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial - PubMed
5 days ago
- #Vitamin D
- #Polycystic Ovary Syndrome
- #In Vitro Fertilisation
- Vitamin D supplementation (4000 IU/day) was tested in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilisation (IVF).
- The study was a multicentre, double-blind, placebo-controlled, randomised clinical trial involving 876 participants across 24 fertility centres in China.
- Primary outcome was live birth rate after the first embryo transfer, with no significant difference found between the vitamin D (52.0%) and placebo (50.2%) groups.
- Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D levels compared to placebo (32.3±11.2 vs 18.2±7.6 ng/mL).
- No significant difference in adverse events, including severe ovarian hyperstimulation syndrome, was observed between the two groups.
- The study concluded that while vitamin D supplementation increases serum levels, it does not improve live birth rates in PCOS patients undergoing IVF.