The Effect of Carnosine Supplementation on Depressive Symptoms and Health-Related Quality of Life in Individuals With Prediabetes and Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial - P
12 hours ago
- #depression
- #diabetes
- #carnosine
- Carnosine supplementation may improve depressive symptoms in individuals with prediabetes and well-controlled type 2 diabetes (T2DM).
- The study involved 38 participants (73.6% male, median age 54.8 years) randomized to carnosine or placebo for 14 weeks.
- Carnosine showed a modest improvement in depressive symptoms (PHQ-8 score mean difference = -2.0; p = 0.03) but no significant change in health-related quality of life (EQ-5D-3L).
- No significant changes were observed in the eight subcomponents of the PHQ-8 scale.
- Further research is needed to confirm these findings in larger and more diverse cohorts.