Clinical efficacy of different biomaterials for the regenerative treatment of periodontal intrabony defects: a systematic review and Bayesian network meta-analysis - PubMed
4 hours ago
- #Biomaterials
- #Periodontal Regeneration
- #Network Meta-Analysis
- Systematic review and Bayesian network meta-analysis compared regenerative treatments for periodontal intrabony defects.
- 32 RCTs and 14 treatment strategies were analyzed using outcomes like probing depth (PD), clinical attachment level (CAL), bone gain, and gingival recession (REC).
- Bone graft combined with platelet-rich fibrin (BoneGraft + PRF) ranked highest for PD reduction (93.6%) and bone gain (94.9%).
- FGF-2 combined with bone graft (FGF2 + BoneGraft) ranked first for CAL gain (91.9%), followed by BoneGraft + PRF (82.6%) and FGF-2 alone (82.4%).
- For REC reduction, PRF combined with ascorbic acid (PRF_AA) ranked best (4.3%), then FGF2 + BoneGraft (9.6%), and PRF (19.6%).
- Combined regenerative approaches with scaffolds and bioactive factors may offer greater clinical benefits than single-material therapies.
- Findings support evidence-based protocol selection but highlight the need for further high-quality RCTs due to limited evidence for some interventions.