Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis - PubMed
5 hours ago
- #Mycobacterium tuberculosis
- #antibiotic resistance
- #L-histidine biosynthesis
- Activation of L-histidine biosynthesis is proposed as a new antibiotic strategy against Mycobacterium tuberculosis.
- Engineered variants of ATP-phosphoribosyltransferase (ATP-PRT) resistant to L-histidine inhibition lead to overproduction of L-histidine.
- Overproduction of L-histidine reduces M. tuberculosis growth by causing nutrient and energy depletion.
- Expression of allosteric variants in M. tuberculosis reduces infections in human macrophages and mouse models.
- Metabolic activation presents a novel mycobactericidal mechanism for antibiotic development.