The Neurogenic Niche: Interactions Among Vessels, Glia, and Neural Stem Cells - PubMed
5 hours ago
- #Neurogenic Niche
- #Neural Plasticity
- #Adult Neurogenesis
- Adult neurogenesis drives neural plasticity in specialized brain microenvironments.
- The hippocampal neurogenic niche involves a functional syncytium of vasculature, glia, and neural stem cells.
- Vessels provide angiocrine support via VEGF and BDNF, while glia manage metabolism and immunity.
- Systemic factors like exercise and the gut-brain axis regulate this niche.
- Niche breakdown is linked to aging, Alzheimer's disease, and chronic stress.
- Translational gaps exist between rodent models and human neurogenesis, with methodological issues affecting data.
- Maladaptive plasticity, such as aberrant neurogenesis, can contribute to conditions like epilepsy.
- Future directions include high-resolution omics and imaging for therapeutic strategies.