Multiple Myeloma and Mimicry: Gastrointestinal Tract Histologic Findings in Patients Following Chimeric Antigen Receptor T-cell Therapy and Anti-CD38 Monoclonal Antibodies - PubMed
5 hours ago
- #Gastrointestinal injury
- #CAR-T therapy
- #Multiple Myeloma
- CAR-T cell therapy targets B-cell maturation antigen in multiple myeloma and CD19 in lymphoid malignancies.
- Study reviewed 14 cases from 8 patients (mean age 63) with gastrointestinal symptoms post-CAR-T therapy.
- Symptoms included diarrhea (88%) and nausea/vomiting (22%), appearing a mean of 294 days post-treatment.
- Endoscopic findings varied from normal to mucosal granularity and ulcers.
- Histologic findings showed regenerative glands, apoptotic epithelial cells, and intraepithelial lymphocytosis.
- Inflammation was minimal with hypocellular lamina propria and decreased plasma cells.
- Immunohistochemical stains were negative for cytomegalovirus and adenovirus.
- Findings suggest CAR-T therapy causes gastrointestinal injury affecting deep mucosa crypts and glands.