OTUD7B attenuates renal fibrosis by regulating PRDX1 protein stability - PubMed
4 days ago
- #PRDX1
- #OTUD7B
- #renal fibrosis
- OTUD7B attenuates renal fibrosis by regulating PRDX1 protein stability.
- Renal fibrosis is a common pathological endpoint in chronic kidney disease (CKD) and end-stage renal disease (ESRD).
- The study investigated the effects of the deubiquitinating enzyme OTUD7B on renal fibrosis and its underlying mechanism.
- OTUD7B was identified through transcriptome sequencing and validated in cellular, animal, and clinical models.
- Overexpression of OTUD7B attenuated renal fibrosis, while knockdown exacerbated it.
- OTUD7B interacts with PRDX1 and reduces SMURF1-mediated K63-linked ubiquitination, preventing lysosomal degradation of PRDX1.
- Targeting the OTUD7B-SMURF1-PRDX1 axis may offer a therapeutic approach for renal fibrosis.