The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation - PubMed
8 days ago
- #microcirculation
- #endothelial ion channels
- #vascular tone
- Endothelial ion signaling is crucial for arterial microcirculation function, regulating local blood flow and systemic arterial pressure.
- The role of endothelial ion channels in vascular resistance has been primarily studied in animal models.
- This review focuses on potassium (K+) channels (KIR2.1, KATP, SKCa/IKCa), TRP channels (TRPV1, TRPV4), and Piezo1 channels in human microcirculation.
- The study examines endothelial ionic signaling in human microvascular beds like skin, skeletal muscle, and brain.
- Different vascular beds utilize distinct endothelial ion channels for vasorelaxant pathways.
- Understanding endothelial channel regulation may lead to new therapies for cardiovascular and neurodegenerative disorders.