Effect of vanzacaftor/tezacaftor/ivacaftor on cystic fibrosis nasal epithelial cells and intestinal organoids compared to elexacaftor/tezacaftor/ivacaftor - PubMed
6 hours ago
- #CFTR modulator therapy
- #cystic fibrosis
- #nasal epithelial cells
- The study compares the effects of vanzacaftor/tezacaftor/ivacaftor (VAN/TEZ/IVA) and elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on cystic fibrosis (CF) nasal epithelial cells and intestinal organoids.
- VAN/TEZ/IVA restored CFTR function to 67% of wild-type levels in nasal epithelial cells, compared to 45% with ELX/TEZ/IVA.
- Both triple combinations showed comparable effects on intestinal organoids using the forskolin-induced swelling (FIS) assay.
- The study highlights the superior discriminatory power of airway epithelial electrophysiology over intestinal organoids for comparing CFTR modulator therapies.
- VAN/TEZ/IVA demonstrated greater CFTR functional rescue in F508del/F508del nasal epithelial cells than ELX/TEZ/IVA.