PD-L1 as a Potential Inducer for NF-κB Pathway Activation in M1-Type Macrophages During Sepsis: An Integrated Analysis Based on GEO Public Database and Multi-Omics Data - PubMed
6 hours ago
- #NF-κB pathway
- #PD-L1
- #sepsis
- PD-L1 may activate the NF-κB pathway in M1-type macrophages during sepsis.
- Study integrates GEO datasets, RNA-seq, IP-MS, molecular docking, and Co-IP.
- PD-L1 expression is elevated in sepsis patients and linked to NF-κB activation.
- PD-L1 interacts with KLF6, a nuclear factor related to the NF-κB pathway.
- PD-L1 shows potential as a prognostic indicator for sepsis.
- PD-L1 knockout mice validate its regulatory role in NF-κB pathway activation in vivo.