Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohypophysis by Activating the cAMP/FOXO1 Pathway - PubMed
6 hours ago
- #adenohypophysis
- #melatonin
- #growth-hormone
- Melatonin promotes growth hormone (GH) synthesis and secretion in the adenohypophysis by activating the cAMP/FOXO1 pathway.
- FOXO1 is identified as a key transcription factor responsive to melatonin, regulating GH synthesis and secretion.
- Melatonin binds to MTNR1A in bovine adenohypophyseal cells, activating the cAMP/PKA signaling pathway and increasing FOXO1 protein expression.
- Dual-luciferase reporter assays confirm FOXO1 binding to the GH1 promoter.
- The study elucidates the molecular mechanism through which melatonin promotes GH synthesis via the cAMP/PKA/CREB/FOXO1 pathway.
- Findings provide insights into melatonin's role in animal growth and development, supporting its potential applications in this field.