Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer - PubMed
4 hours ago
- #intratumoral bacteria
- #chemoimmunotherapy
- #colorectal cancer
- Intratumoral bacteria, like Fusobacterium nucleatum, promote immunosuppression in colorectal cancer by degrading MHC-I and upregulating PD-L1.
- A targeted liposomal nanotherapy (HA@Ag NPs/PTX Cls) combines silver nanoparticles to eradicate bacteria and paclitaxel to induce apoptosis, enhancing chemoimmunotherapy.
- The nanotherapy restores microbial homeostasis, boosts MHC-I antigen presentation, increases TNF and IFN production, downregulates PD-L1, and inhibits primary and metastatic tumors.
- Bacterial clearance triggers long-term immunological memory, offering durable protection against tumor recurrence by remodeling the immune microenvironment.