Addressing unmet needs in rheumatoid arthritis: the challenge of translating multi-omics into precision therapies - PubMed
6 hours ago
- #precision-medicine
- #multi-omics
- #rheumatoid-arthritis
- Rheumatoid arthritis (RA) is a highly heterogeneous chronic systemic inflammatory disease.
- 30-40% of patients do not respond adequately to current biologic agents and Janus kinase inhibitors.
- Multi-omics technologies (genomics, transcriptomics, proteomics, metabolomics, microbiomics, epigenetics, cytomics) offer new insights into RA mechanisms.
- Challenges remain in translating multi-omics into clinical practice, including data integration, clinical validation, and technological optimization.