Protective effects of dog allergen and endotoxin for lung function and asthma - PubMed
7 hours ago
- #gene-environment-interactions
- #asthma
- #lung-function
- Childhood asthma is influenced by gene-environment interactions, particularly with allergens.
- Higher levels of dog allergen (Can f1) in infancy significantly decrease the risk of asthma by age 5 (OR 0.52, 95% CI 0.25, 0.98).
- Exposure to high Can f1 levels is associated with improved lung function (FEV1 z-scores β=0.23, 95% CI 0.06, 0.40), regardless of asthma status.
- Gene-environment interactions show that Can f1 exposure may modulate lung function in individuals with low polygenic scores (PGSs).
- Early-life exposure to high Can f1 levels is linked to improved lung function and protection against asthma in a general population birth cohort.