NMI promotes the secretion of IL-17 and exacerbates psoriasis - PubMed
11 hours ago
- #Psoriasis
- #NMI
- #IL-17
- NMI, a damage-associated molecular pattern (DAMP), modulates T helper 17 (Th17) cell activity and is involved in psoriasis pathogenesis.
- Elevated NMI expression in psoriatic skin lesions correlates with increased IL-17 levels.
- Nmi deficiency (Nmi-/-) in mice reduces skin inflammation and lowers IL-17A and IL-17F expression.
- NMI promotes IL-17A and IL-17F secretion from Th17 cells via interaction with Toll-like receptor 4.
- Therapeutic neutralization of NMI with specific antibodies alleviates psoriatic symptoms in mice.
- NMI is identified as an endogenous enhancer of Th17-mediated immunity and a potential therapeutic target for psoriasis.