Acanthamoeba castellanii: Non-Steroidal Anti-Inflammatory Drugs Affect Adhesion, Motility, and Encystment, Suggesting a Link with a gp63-like Protein Candidate - PubMed
5 hours ago
- #gp63-like protein
- #Acanthamoeba castellanii
- #Non-Steroidal Anti-Inflammatory Drugs
- NSAIDs (acetylsalicylic acid, ibuprofen, diclofenac) reduce adhesion, migration, and encystment in Acanthamoeba castellanii.
- Drug-treated co-cultures preserve host cell actin fluorescence, suggesting reduced parasite-induced cytoskeletal disruption.
- Increased colocalization of a gp63-like protein with F-actin in cysts and migrating trophozoites implies its involvement in NSAID-sensitive pathways.