Complete immunosuppression withdrawal after liver transplantation: An International Multicenter Study - PubMed
5 hours ago
- #liver transplantation
- #operational tolerance
- #immunosuppression withdrawal
- Complete immunosuppression withdrawal (ISW) after liver transplantation is feasible in selected patients, improving metabolic conditions like diabetes and hypertension.
- A retrospective multicenter study of 287 patients showed no immunologically mediated graft loss after ISW, with a 93% five-year survival rate.
- While ISW led to operational tolerance in 43.5% of biopsied patients, mild worsening fibrosis or new inflammation occurred in some, without impacting mortality.
- The most common reasons for ISW were clinical trial participation, patient decision, and side effects, with a median withdrawal time of 9.4 years post-transplant.
- Future research aims to safely expand ISW to more liver transplant patients, despite some histological changes observed in the graft.