Assessment of female fertility and oocyte quality in mice after exposure to polystyrene microplastics and polybrominated diphenyl ethers, alone and in combination - PubMed
5 hours ago
- #Oxidative Stress
- #Microplastics
- #Female Fertility
- Polystyrene microplastics (Ps-MPs) and polybrominated diphenyl ethers (PBDE-47) alone and in combination impair female fertility and oocyte quality in mice.
- Co-exposure to Ps-MPs and PBDE-47 causes the most severe damage, including reduced ovarian weight, decreased follicles, increased atresia, and lower ovulation and litter size.
- Oocyte defects include disrupted meiotic maturation, abnormal spindle formation, mitochondrial dysfunction, oxidative stress, DNA damage, and apoptosis.
- Mechanisms involve synergistic effects on mitochondrial dysfunction, autophagy-lysosome imbalance, and oxidative stress-mediated DNA damage.