The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics - PubMed
4 hours ago
- #YAP
- #mechanotransduction
- #NEMP1
- NEMP1 is essential for fertility, with its loss leading to oocyte death in the mechanically challenging ovarian cortex.
- Softening the ovary rescues oocyte loss and restores fertility in Nemp1 knockout mice.
- NEMP1 depletion leads to cell death on stiff substrates but cells survive on soft substrates.
- NEMP1 regulates YAP nuclear translocation, crucial for mechanotransduction.
- Loss of NEMP1 disrupts actin organization, and inducing actin polymerization partially rescues nuclear YAP.
- NEMP1 forms a complex with NESPRIN's KASH domain, strengthening the actin cytoskeleton to withstand mechanical forces.
- The Nemp1-Nesprin complex supports a mechanosensitive pathway parallel to the LINC complex.