IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity - PubMed
3 days ago
- #Neuronal Hyperactivity
- #Autoimmune Disease
- #Tau Pathology
- Anti-IgLON5 disease involves autoantibodies targeting IgLON5, leading to brain dysfunction and Tau pathology.
- Patient-derived α-IgLON5 antibodies cause IgLON5 clustering with other proteins, triggering neuronal hyperactivity.
- This hyperactivity leads to pathological Tau missorting and phosphorylation, similar to early neurodegenerative diseases.
- In wild-type mice, α-IgLON5 antibodies induce hippocampal Tau phosphorylation and neuroinflammatory responses.
- The findings establish a causal link between α-IgLON5 antibodies and Tau pathology, with neuronal hyperactivity as a key driver.