Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling - PubMed
a day ago
- #computational model
- #genetic variants
- #RNA-protein interactions
- Development of BRIDGE, a unified model linking RNA sequence-structure motifs with functional effects of genetic variants.
- BRIDGE outperforms existing methods in static predictions and adapts to unseen cellular contexts without retraining.
- The model identified 3,571 integrative motifs, some associated with splicing regulation, and provides interpretable insights into variant impacts.