Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in children: a multicenter prospective study on behalf of the Porto IBD Working Group of ESPGHAN - PubMed
5 hours ago
- #pediatric gastroenterology
- #intestinal ultrasound
- #ulcerative colitis
- Study evaluates intestinal ultrasound scan (IUS) for predicting treatment outcomes in pediatric acute severe ulcerative colitis (ASUC).
- Multicenter prospective study conducted across ten European centers with biologic-naïve children.
- Key metrics: colonic wall thickness (CWT), colonic wall stratification (CWS), and colonic wall blood flow via power Doppler.
- Non-responders to corticosteroids had higher CWT and more frequent hypervascularity in specific colonic quadrants.
- Optimal cut-offs for predicting steroid resistance: LLQ CWT >5 mm and Milan Ultrasound Criteria (MUC) >7.8.
- 16.7% of patients required colectomy within 8 weeks; CWT >4.8 mm and MUC >8.7 in LLQ were associated with medical therapy failure.
- Patients in steroid-free clinical remission at week 8 had lower CWT and MUC at second IUS.
- Conclusion: IUS is effective for predicting therapy failure and need for colectomy in ASUC.