Triglyceride glucose index-a body shape index (TyG-ABSI) outperforms traditional obesity indices in predicting all-cause and cardiovascular mortality in metabolic-dysfunction associated steatotic live
10 hours ago
- #mortality prediction
- #TyG-ABSI
- #MASLD
- TyG-ABSI, a composite index of insulin resistance and visceral adiposity, outperforms traditional obesity indices in predicting all-cause and cardiovascular mortality in MASLD.
- The study included 7515 adults with MASLD from NHANES (1999-2018), showing TyG-ABSI had higher predictive accuracy (AUC) and significant Net Reclassification Improvement (NRI) compared to other indices.
- Participants in the highest TyG-ABSI quartile had significantly higher risks of all-cause mortality (HR 1.49) and cardiovascular mortality (HR 2.32) compared to the lowest quartile.
- Mediation analysis revealed that accelerated biological aging significantly mediated mortality risks, explaining 24.75%-46.53% of the associations.
- TyG-ABSI is highlighted as a robust, independent predictor for mortality in MASLD, useful for enhanced risk stratification in clinical practice.