ZFP36L1 promotes non-small cell lung cancer progression under hypoxia by modulating CXCL9:SPP1 polarity: A single-cell transcriptomic study - PubMed
5 hours ago
- #non-small cell lung cancer
- #macrophage polarization
- #ZFP36L1
- ZFP36L1 promotes non-small cell lung cancer (NSCLC) progression under hypoxic conditions.
- Hypoxia induces an imbalance in macrophage CXCL9:SPP1 ratio, favoring pro-tumor SPP1+ macrophages over anti-tumor CXCL9+ macrophages.
- ZFP36L1 upregulation drives macrophage polarization toward the SPP1+ phenotype.
- SPP1+ macrophages bind to CD44 on tumor cells, accelerating NSCLC malignancy.
- ZFP36L1 transcriptionally regulates SPP1, reducing the CXCL9:SPP1 ratio and contributing to NSCLC progression.
- Findings were validated using single-cell transcriptomics, in vitro co-culture assays, patient-derived organoids, and a macrophage-specific ZFP36L1-knockout mouse model.