Effectiveness of GLP-1 Receptor Agonists in Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials - PubMed
4 hours ago
- #Meta-analysis
- #Polycystic ovary syndrome
- #GLP-1 receptor agonists
- This systematic review and meta-analysis evaluates the effectiveness of GLP-1 receptor agonists (GLP-1 RAs) in women with polycystic ovary syndrome (PCOS).
- GLP-1 RAs significantly reduce body mass index (BMI) and improve insulin resistance (HOMA-IR) compared to control interventions like metformin or placebo, with liraglutide and exenatide showing particular benefits.
- No significant overall effect on total testosterone levels was found, and the evidence certainty was moderate for BMI and HOMA-IR but very low for testosterone, indicating the need for further large-scale studies on long-term outcomes.