The effects of microplastics and nanoplastics on cardiovascular disease: mechanisms and perspectives - PubMed
5 hours ago
- #environmental health
- #cardiovascular disease
- #microplastics
- Microplastics and nanoplastics (MNPs) are pervasive environmental pollutants from plastic degradation and product use.
- MNPs can enter the bloodstream and accumulate in cardiovascular tissues, potentially contributing to cardiovascular disease.
- Current research examines MNP exposure routes, distribution in tissues, and biological effects on cardiovascular health.
- Clinical and experimental studies show MNPs in blood, atherosclerotic plaques, thrombi, and myocardial tissue.
- Mechanistic links include oxidative stress, mitochondrial dysfunction, inflammation, and fibrotic remodelling.
- Causal associations in humans remain unproven due to methodological challenges like inconsistent detection methods.
- Research priorities include better detection methods, more epidemiological data, and real-world exposure modelling.
- The global issue of plastic pollution makes understanding MNP cardiovascular risks an urgent public health challenge.