NSMCE2 dispensability in mouse spermatogenesis suggests functional redundancy within the meiotic repair network - PubMed
7 hours ago
- #meiosis
- #NSMCE2
- #spermatogenesis
- NSMCE2, a SUMO E3 ligase subunit, is dispensable for mouse spermatogenesis and male fertility.
- Germline deletion of Nsmce2 showed no impairment in spermatogenesis, meiotic progression, or DNA repair.
- Upregulation of PIAS1 suggests compensatory mechanisms maintain SUMOylation homeostasis in NSMCE2 deficiency.
- The study highlights functional redundancy and robustness in the meiotic DNA repair network.