Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study - PubMed
4 hours ago
- #Metabolic Reprogramming
- #Macrophage Polarization
- #Preeclampsia
- The study identified four endoplasmic reticulum stress (ERS)-related genes (HTRA1, GBA1, KL, PC) as potential diagnostic biomarkers for preeclampsia, showing high discriminatory power (AUC = 0.846).
- These genes are linked to metabolic reprogramming pathways, including central energy metabolism, amino acid metabolism, short-chain fatty acid metabolism, and redox homeostasis.
- Immune infiltration analysis revealed that KL and PC negatively correlate with M1 macrophages but positively with M2, while HTRA1 and GBA1 show the opposite correlation, indicating a role in M1 macrophage polarization.
- Molecular docking demonstrated stable binding between aspirin and the proteins encoded by the signature genes, suggesting a potential therapeutic interaction.