Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis - PubMed
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- #ALS
- #glymphatic dysfunction
- #white matter degeneration
- Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in ALS.
- ALS patients show reduced DTI-ALPS index, increased cortical free water fraction (FWF), altered white matter FWF, and reduced free-water-corrected fractional anisotropy (fwcFA) compared to healthy controls.
- Imaging metrics correlate with functional, cognitive, and emotional outcomes, with mediation pathways suggesting indirect associations between glymphatic dysfunction and clinical measures.
- Multi-compartment diffusion imaging offers complementary markers for brain microstructure and clinical relevance in ALS.