Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress - PubMed
5 hours ago
- #Metabolic homeostasis
- #Nfil3
- #Gut-liver axis
- Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.
- Disruption of circadian regulation and gut microbial homeostasis is linked to metabolic dysfunction in steatotic liver disease (MASLD).
- Nfil3 connects microbial functional states to hepatic metabolic and immune responses under high-fat diet (HFD) stress.
- Probiotic VSL#3 supplementation mitigates HFD-associated metabolic and inflammatory alterations in mice.
- Nfil3-deficient mice show attenuated responses to HFD-induced metabolic and inflammatory changes.
- VSL#3 enriches SCFA- and mucin-associated gut bacteria while suppressing endotoxin-associated bacteria.
- Nfil3 acts as a regulatory node linking microbial functional potential with immune and metabolic responses in MASLD.