Ecotypes of triple-negative breast cancer in response to chemotherapy - PubMed
3 hours ago
- #Triple-negative breast cancer
- #Single-cell analysis
- #Chemotherapy response
- TNBC is aggressive and treated with chemotherapy, but only half of patients respond well.
- Single-cell transcriptomic analysis of 427,857 cells from 101 patients and spatial transcriptomic analysis of 44 patients.
- TNBC tumors classified into 4 patient-level subtypes based on cancer-cell gene expression.
- 13 metaprograms identified reflecting intra-tumoral heterogeneity at the single-cell level.
- Tumor microenvironment consists of 49 immune and stromal cell states, many reprogrammed.
- Eight distinct cellular communities (ecotypes) based on co-occurrences and spatial organization.
- Macrophage subtypes and cancer-cell metaprograms are key for good chemotherapy response.
- Insights into untreated TNBC biology and its association with chemotherapy response.