Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection: Kupffer cell plasticity - PubMed
4 days ago
- #macrophage plasticity
- #mycobacterial infection
- #Kupffer cells
- Kupffer cells (KCs) exhibit unique functional and immunophenotypic features among tissue-resident macrophages.
- Mycobacterial infections induce the emergence of a unique KC subset (KClow) derived from embryonically seeded KCs, lacking signature markers CLEC4F and VSIG4.
- KClow cells are specialized antimycobacterial effector cells with heightened iNOS production, adapted to hypoxic microenvironments, and modulate adaptive immune responses.
- Monocyte-derived macrophages are localized at granuloma peripheries and crucial for granuloma initiation.
- KCs demonstrate remarkable plasticity in response to chronic mycobacterial infections, contrary to the traditional view of limited plasticity.
- The study highlights the organ-specific response of KCs to chronic mycobacterial infections.