Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization - PubMed
4 hours ago
- #microbiome
- #chronic stress
- #periodontitis
- Chronic restraint stress (CRS) exacerbates periodontitis by causing oral microbial dysbiosis and altering host metabolism.
- Depressive symptoms are significantly correlated with the severity of periodontitis, linked to a distinct oral microbiome.
- Fecal microbiota transplantation from CRS-exposed mice to germ-free mice transmitted heightened periodontitis, confirming stress-altered microbiota's causal role.
- Metabolomic profiling revealed a depletion of eicosapentaenoic acid (EPA) in stressed mice with ligature-induced periodontitis.
- EPA supplementation alleviates periodontitis by inhibiting the NF-κB pathway, reducing pro-inflammatory M1 macrophage polarization.
- The study highlights a novel gut-oral axis mediated by microbiota and metabolites under stress, with EPA as a potential therapeutic agent.