Peptidomics: A New Dimension in Microbiome Research - PubMed
5 hours ago
- #Biomarkers
- #Microbiome
- #Peptidomics
- The human gut microbiome significantly influences health, including neurodegeneration, metabolism, immunity, and pharmacological responses, with imbalances linked to diseases like Alzheimer's and Parkinson's.
- Current methods like metagenomics, metatranscriptomics, and metabolomics provide insights but are incomplete, lacking direct analysis of functional peptides that signal microbiome-host interactions.
- Peptidomics, enabled by advanced LC-MS/MS techniques and AI-assisted sequencing, directly captures unstable signaling peptides and proteolytic fragments, offering a functional layer missing from other approaches.
- Recent studies show peptidomics can uncover microbial roles in gut inflammation, modulate the gut-brain axis, and enable disease stratification in conditions like inflammatory bowel disease, highlighting its potential as a biomarker and therapeutic tool.
- Integrating peptidomics with existing omics methods will provide a more comprehensive view of the microbiome, accelerating biomarker discovery, refining diagnostics, and expanding peptide-based therapeutics in microbiome research.