Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis - PubMed
5 hours ago
- #Skin Atlas
- #Atopic Dermatitis
- #Immune-Stromal Community
- A multi-modal skin atlas was created using 280,518 cells from whole skin tissue samples of 17 adults, including 11 atopic dermatitis (AD) patients.
- The study identified a multicellular immune-stromal community in AD, linked to disrupted cornification and specific T cell expansion.
- Key components of this community include MMP12+ and migratory dendritic cells, cycling innate lymphoid cells, natural killer cells, inflammatory fibroblasts, and clonally expanded T cells.
- Disrupted cornification and subsets of this immune-stromal community were enriched in GWAS, suggesting their role in initiating AD.
- The research highlights disease-associated cell subsets and interactions in chronic skin inflammation, providing insights into AD pathogenesis.